Main manager Steve Adams had several players out with injury but he was only forced into one change, with Danny White in for Matt Wragg.
Main were the first to show with Rob Branagan forcing Paul Metcalfe into a save low down following his powerful header.
Dave Hattersley was forced to palm away Steve Harrop's freekick from the edge of the area and Danny White cleared the danger.
John Baross then fired high over the bar from 20 yards from goal after a great bit of pressure from the visitors.
Main took the lead in the 21st minute when Branagan smashed the ball into the right side of the goal following Danny Patterson's ball to Mick Baker and his defence splitting through ball.
Main doubled their lead in the 27th minute when Greg Mason controlled Danny Reilly's ball forward and rocketed the ball over Metcalfe and into the top corner.
Mason could have had his second a minute later when his shot was tipped narrowly over the bar following Chris Dickman's ball forward.
Branagan forced Metcalfe to tip his header out for a corner in the 37th minute following skipper Paul Staniforth's curling freekick.
A minute before half-time Branagan was sent through on goal but his chip was easily caught by Metcalfe.
In first half injury time Branagan raced down the wing and looped a cross into the area and Mason latched on to the ball but his header flew over the bar.
In the 57th minute Mason played the ball through for Branagan who rounded Metcalfe but he was unable to get the ball out of his feet and Metcalfe collected his shot.
The visitors pulled a goal back in the 58th minute when Chris Ridley benefitted from a fumbled back pass from Sean Lee and sidefooted the ball into the goal.
The visitors were level in the 68th minute when Ridley slotted the ball under Hattersley after Scott McDonald Cleared the ball straight to the winger's feet.
A minute later the comeback was complete when Phil Jackman side-footed into an empty net after Hattersley fumbled Metcalfe's long kick.
Hattersley was then sent off for a deliberate hand ball outside of his penalty area. Staniforth donned the keeper's jersey and gloves with Main down to 10 men.
From the resulting free kick Harrop hit Reilley in the Main wall.
Town could have sealed the result in the 86th minute when Baross was sent clear through on goal, but his shot flew well wide of the Main goal.
A minute from time Mason looked to have taken the match to a replay when he chipped Metcalfe from a tight angle 20 yards from goal.
But there was a final twist in the tail when Jackman raced down the wing and lofted the ball into the area but it was deflected past Staniforth and into the goal by McDonald.
Main travel to Eccelshill United tomorrow (kick off 3pm) and the Game against Brodsworth scheduled for Bank Holiday Monday the 25th has been switched to an away game kick off 3pm.